Heatstroke is the most serious and deadly form of heat-related illnesses. Your body temperature gauge basically breaks, and you keep getting hotter without the natural ability to cool down again.
This can happen quickly, and the best defense is to stay hydrated and not overwork yourself in the heat.
Heatstroke can come on suddenly by itself, or arise as a complication or worsening of heat exhaustion.
Heatstroke is very serious, and untreated can result in brain injury, organ injury, or death.